Endocrine Abstracts

Introduction: In addition to safety and efficacy, patient satisfaction with treatment is potentially a key factor in maintaining therapy adherence. Testosterone replacement therapy (TRT) is provided using a variety of products with different features and routes of administration. These differing product characteristics may impact on patient satisfaction and adherence with a concomitant impact on well-being and health-related quality of life. The aim of this study was to explor...

High dose steroids are effective in treating active thyroid-associated ophthalmopathy (TAO), however the side effects are considerable. This study aimed to establish whether long term response to intravenous methylprednisolone can be predicted by a detailed ophthalmological assessment 1 to 2 weeks after the first dose of steroid.45 patients with moderate to severe, active TAO (including 31 with optic neuropathy), treated with intravenous methylprednisolo...

Acromegaly and thyroid-associated ophthalmopathy(TAO) are uncommon diseases with different pathogenetic mechanisms.We report two patients with acromegaly and TAO and speculate on a possible association.A 54 year old man with subclinical hypothyroidism and strongly positive thyroid microsomal antibodies presented with features of TAO.MRI of his orbits confirmed the diagnosis.Clinical examination also revealed features suggestive of acromegaly,which was co...

Objective: Evidence shows that IGF-1 receptor (IGF-1R) antagonism reduces the inflammation and proptosis that occur in thyroid eye disease (TED). VRDN-001 is a full antagonist to IGF-1R, and VRDN-003 is a next-generation, half-life extended version of VRDN-001 designed to enable subcutaneous (SC) administration. We compared the in vivo pharmacokinetic (PK) parameters of VRDN-001 and VRDN-003 and used a PK model to simulate potential VRDN-003 SC dosing regimens.<p ...

Increased 11β hydroxysteroid dehydrogenase type 1 (11βHSD1) activity is implicated in the development of the metabolic syndrome. Identifying natural compounds that influence 11βHSD1 activity could lead to novel methods of treating obesity, cardiovascular disease and diabetes. In the present study, we tested the effect of green coffee bean extract (GCBE), rich in chlorogenic acid (CGA), in human volunteers and of CGA in mice on blood pressure (BP), lipid and gluc...

Introduction: The aetiology of Graves’ orbitopathy (GO) is complex and includes genetic and environmental influences. Among potentially controllable risk factors smoking ranks highest. There is strong evidence that smoking cessation benefits patients with GO. The success of secondary prevention strategies depends largely on how the intervention is perceived by patients, especially when it involves lifestyle changes.Objectives: To determine patient p...

Radioidine (RI) has been implicated as an adverse factor causing deterioration of Thyroid-Associated Ophthalmopathy (TAO). Oral steroids administered after RI appear to protect patients' eyes, and this practice is now widespread. Two factors may confound the controversy surrounding the effects of RI on TAO. Firstly hypothyroidism, which is common after RI and is independently detrimental to the eyes, and secondly studying patients who are in different phases of the natural his...

The importance of the differentiation between the apparent benign clinical condition of macroprolactinaemia and that of true hyperprolactinaemia, which requires therapy, is becoming widely recognised. Laboratories routinely rely on prolactin recoveries of less than 40 percent following treatment of sera with polyethylene glycol (PEG) to distinguish between the former and latter conditions. However, the 40 percent threshold employed is arbitrarily defined with little scientific...

High dose intravenous methylprednisolone therapy is used in patients with severe thyroid-associated ophthalmopathy (TAO) and other inflammatory disorders. Although in the short-term it appears to be safe, the acute metabolic effects of this regimen have not been studied in detail.We studied 15 patients with severe TAO, aged 59 ± 10 (mean ± SD) years. One patient was known to have type 2 diabetes. Each patient received 500 mg of iv methyprednisolone daily on t...

Thyroid hormones are evolutionarily conserved iodine-containing regulators of metabolism and development (reviewed by Mullur et al. (2014)). A key process in synthesis of the effectors thyroxine and tri-iodothyronine is the uptake of iodide from the bloodstream into thyroid follicular cells by the sodium-iodide symporter channel (NIS) encoded by the solute-carrier gene SLC5A5. Perturbation of NIS activity by environmental chemicals can lead to rapid and potent changes...